Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors

Desensitization of 5-HT1A receptors by 5-HT2A receptors in neuroendocrine neurons in vivo.

An imbalance between serotonin-2A (5-HT2A) and 5-HT1A receptors may underlie several mood disorders. The present studies determined whether 5-HT2A receptors interact with 5-HT1A receptors in the rat hypothalamic paraventricular nucleus (PVN). The sensitivity of the hypothalamic 5-HT1A receptors was measured as oxytocin and adrenocorticotropic hormone (ACTH) responses to the 5-HT1A receptor agon...

The therapeutic role of 5-HT1A and 5-HT2A receptors in depression.

The selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressant drugs, because they are well tolerated and have no severe side effects. They rapidly block serotonin (5-HT) reuptake, yet the onset of their therapeutic action requires weeks of treatment. This delay is the result of presynaptic and postsynaptic adaptive mechanisms secondary to reuptake inhibit...

CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors.

Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioral and biochemical responses in CB(1) receptor knockout mice. CB(1) knockout animals exhibited a significant reduction in the induction of head twitches and paw tremor by the 5-HT(2A/C) receptor selective agonist (+/-) DOI, as well as a reduced hypothermic response fo...

Estrogen treatment blocks 8-OH-DPAT- and apomorphine-induced disruptions of prepulse inhibition: Involvement of dopamine D1 or D2, serotonin 5-HT1A, 5-HT2A or 5-HT7 receptors*

The role of 5-HT2A and 5-HT2C receptors on harmalineinduced eating behavior in 24-h food-deprived broiler cockerels

This study was designed to examine the effects of intracerebroventricular (ICV) injection of ketanserin(5-HT2a receptor antagonist) and SB242084 (5-HT2c receptor antagonist) on harmaline induced feeding anddrinking response in 24-h food-deprived (FD24) broiler cockerels. At first, guide cannula was surgicallyimplanted in the right lateral ventricle of chickens. In experiment 1, birds were injec...